Acid-Base Physiology
11.3 Acid-Base Disorders due to Drugs & Toxins [  DRAFT ONLY ]

Classification by Mechanism

Drug-induced acid-base disorders:

1. Metabolic acidosis induced by large acid loads
- from exogenous sources (e.g. NH4Cl, or toxin ingestion) 
- from endogenous acid production (e.g. generation of ketoacids or lactic acids by alcohol or phenformin)
- from base loss (eg laxative abuse).

2. Renal tubular acidosis  

2. Metabolic alkalosis resulting from exogenous bicarbonate loads or effective extracellular fluid contraction, potassium depletion plus hyperaldosteronism

4. Respiratory acidosis from drug-induced respiratory depression or neuromuscular impairment

5. Respiratory alkalosis from drug-induced hyperventilation

Some Drugs & Toxins which have been involved in various Acid-Base Disorders

Respiratory Acidosis

  • CNS depressants

  • Narcotics

  • Muscle Relaxants

High Anion Gap Metabolic Acidosis

Renal Tubular Acidosis

  • Amphotericin B 

  • Acetazolamide

  • Toluene

  • Lithium

  • Cyclamate

  • Analgesics

  • Carbonic Anhydrase Inhibitors (eg acetazolamide)

  • Lead

  • NSAIDs

  • Outdated tetracycline

  • Pentamidine in AIDS patients

Other causes of Hyperchloraemic Metabolic Acidosis

  • Potassium-sparing diuretics

  • Acidifying infusions (eg HCl, NH4Cl, lysine-HCl & arginine-HCl infusions)

  • CaCl2 ingestion (loss of HCO3 due to precipitation of carbonate)

Respiratory Alkalosis

  • Salicylates

  • Propanidid

Metabolic Alkalosis

  • Emetics

  • Diuretics


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